A new locus for arrhythmogenic right ventricular cardiomyopathy (ARVD2) maps to chromosome 1q42-q43
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چکیده
منابع مشابه
Arrhythmogenic Right Ventricular Cardiomyopathy
Arrythmogenic right ventricular (RV) cardiomyopathy (ARVC) is a cardiomyopathy characterized pathologically by fibrofatty replacement primarily of the RV and clinically by life-threatening ventricular arrhythmias in apparently healthy young people. The prevalence of the disease has been estimated at 1 in 5,000 individuals, although this estimate will likely increase as awareness of the conditio...
متن کاملArrhythmogenic right ventricular cardiomyopathy.
Arrhythmogenic right ventricular cardiomyopathy (ARVC) has evolved from postmortem pathology at to a diagnosable clinical condition, and holds promise for definitive genetic diagnosis. Its prevalence is between 1/1,000 and 1/5,000, with 10% of deaths occurring before age 19 and 50% before age 35. When analyzed against age-specific norms, the electrocardiography (ECG) and signal-averaged ECG (SA...
متن کاملA new locus for arrhythmogenic right ventricular dysplasia on the long arm of chromosome 14.
Familial arrhythmogenic right ventricular cardiomyopathy or dysplasia (ARVD) is an idiopathic heart muscle disease with an autosomal-dominant pattern of transmission, characterized by fibro-fatty replacement of the right ventricular myocardium and ventricular arrhythmias. Recently, linkage to the chromosome 14q23-q24 (locus D14S42) has been reported in two families. In the present study, three ...
متن کاملArrhythmogenic Right Ventricular Cardiomyopathy/Dysplasia1
Arrhythmogenic right ventricular cardiomyopathy/dysplasia (ARVC/D) is characterized by the patchy replacement of myocardium by fatty or fibrofatty tissue. These changes lead to structural abnormalities including right ventricular enlargement and wall motion abnormalities that can be detected by echocardiography, angiography, and cine MRI. ARVC/D is a genetically heterogeneous disorder, since it...
متن کاملArrhythmogenic right ventricular dysplasia/cardiomyopathy.
The heart is a 4-chambered pump that propels blood simultaneously to the lungs and the rest of the body by means of coordinated muscular contraction. Various diseases can affect the heart muscle and cause it to become weak, thus decreasing its ability to pump blood adequately. Disease that weakens the heart muscle is called cardiomyopathy. Some causes of cardiomyopathy are viral infections of t...
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ژورنال
عنوان ژورنال: Human Molecular Genetics
سال: 1995
ISSN: 0964-6906,1460-2083
DOI: 10.1093/hmg/4.11.2151